The museum is housed in an early 20^th century Neoclassical building in the centre of Kozani, which the Municipality has donated to the Archaeological Service. It operated normally until the earthquake of June 1995, since when it has been under repair, owing to the damage caused by the quake. The museum will re-open when the work is finished. For the time being, all the exhibits are in storage.

The museum has finds made by archaeologists during excavations and by members of the public from all over Kozani prefecture, apart from the Aiani area. They include sculptures, inscriptions, statues, reliefs, clay vessels, figurines, and gold, silver, and bronze jewellery, all dating from the Palaeolithic to the Roman period.

The first room displayed metal exhibits mainly from the necropolis of Kozani (bronze jewellery, metal vessels, kylikes, typical weapons, gold and silver jewellery, and silver coins), dating from the Iron Age to the 3^rd century bc. The second room had examples of pottery, stonework, and koroplastics from all periods from Palaiokastro, Kitrini Limni, Metamorfossi, the Kozani necropolis, Anarrahi, Apidea, and Eratyra.

In the third room were marble statuettes and stelai, votive offerings from sanctuaries of the gods, and an honorary stele mentioning the boule and the deme, from various parts of the prefecture and dating to Hellenistic and Roman times. In the fourth room were displayed a marble stela with copious information about the area of Eordaia in the early 2^nd century bc, marble grave and votive stelai, and three statues (the lower part of a female statue, a marble statuette of a child, and the marble head of a woman, all dating to the 4^th century bc).