Established in 1978 as a non-profit cultural and educational institution, the museum offers the public an appropriate environment for learning about and understanding the achievements of science and technology. It is housed in a building of 2,000 m² provided by the Hellenic Industrial Development Bank in Sindos, the industrial area of Thessaloniki.

It displays exhibits relating to the historical development of technology, hands-on exhibits from the domains of physics and chemistry, and numerous other exhibits illustrating technical culture.

There are two exhibition spaces.

I. Technology. Objects and multimedia information grouped by theme in the following areas: Ancient Greek Technology, Spinning and Textile Making, Printing, Electricity, Telecommunications, New Telecommunications Technologies, Electronic Computers, Radio and Television, Amateur Radio, Navigational Instruments, Oil, Rubber, Automobiles, the Railway, Aviation, Air Traffic Control Tower Telecommunications, Human Beings in Space, Meteorology, Instruments for Physics Experiments, Photography, Holograms, Audio-visual Media, Traditional Technology, Medical Apparatus and Instruments.

II. Technopark. Hands-on exhibits, which visitors are invited to operate and thus understand, in a practical and entertaining way, phenomena and laws of the natural sciences.

The museum also offers guided tours and demonstrations of its exhibition spaces, organises temporary exhibitions, publishes books, has set up the Creation and Innovation Centre, organises conferences, and promotes its educational aspect with events addressed to children aged 11–18.

In this context, it celebrated the turn of the millennium, in association with the Ministry of Macedonia and Thrace, by organising a biotechnology exhibition in Warehouse 3 in the port (1 October – 15 December 1999). The purpose of the exhibition was to help people form personal opinions about future aspects of biotechnology that are of increasing concern to society.